Dr.Jamil Ahmad
RCMS NUST
Sector H12 Islamabad
Ph. 0092-51-90855726
dr.ahmad.jamil@gmail.com


Personal



Date and place of birth : 1973 in Saidu Sharif, Pakistan
Languages : Pashto, Urdu, English, French
Interests : Badminton, Squash, Field hockey, Uni-hockey, Cricket,
Hiking



Research Interests




Bioinformatics: Biological regulatory networks, Neural networks
Model checking
Software Engineering: Use of formal methods in the design of complex software systems
Modeling and Verification of embedded, reactive, real-time computer system




Techniques and Tools



• Hybrid Automata / HyTech, PHAVer, d/dt
• Timed Automata / UPPAAL
• Markov Chain/ PRISM
• Promela / SPIN
• Polyhedra/ PolyLib and Barvinok



Current Research



My current research focuses on the hybrid modeling and analysis of biological regulatory networks (BRN) and neuron action potential. The parameters in our models are the activation and inhibition time delays. For the analysis of hybrid models, I use the model checking tool HyTech and PHAVer to synthesize parametric constraints characterizing cyclic or non-cyclic behaviors. For the stability analysis of the cyclic behavior, I use polyhedral libraries, PolyLib and Barvinok, to compute the volume and diameter of the invariance kernel (cyclic regions in the state space) of BRN. The featuring measures volume and diameters are expressed in terms of delay parameters, and which predict the stability and emptiness of the invariance kernel. I also work on the modeling and reachability analysis of neuron action potential, synaptic plasticity and Hebbian learning.



Academics



Post-Doc (Bioinformatics, 2010), University of Konstanz Germany

PhD (Applied Computer Science & Bioinformatics, 2009), Ecole Centrale de Nantes, France

MS (Embedded Computer Science, 2005) Ecole Centrale de Nantes, France

MSc (Computer Science, 1997) Peshawar university, Pakistan



Publications



1.      Ahmad J,Niazi U, Mansoor S, Siddique U, Bibby J (2012) Formal Modeling and Analysis of the MAL-Associated Biological Regulatory Network; Insight into Cerabral Malaria. PLoS ONE 7(3): e33532 doi;10.1371/journal.pone0033532

2.       Mahum Riaz, Sayeda Sadaf, Beena Gul,  Jamil Ahmad “Boolean Modeling of the Half Centre Rhythm Generator Including Fast Persistent Inward Currents”, Accepted in iCBBE , 2012

3.    Shah Khusro, Jamil Ahmad, and Azhar Rauf,  “User Modeling: From Early Shell Systems to the Desktop and Smartphones”, PUTAJ Sciences, ISSN 2219-2468, vol. 18-2011, p. 293-30, 2011

4.      Usman Rauf, Umair Siddique Jamil Ahmad and  Umar Niazi, “Formal Modeling and Analysis of Biological Regulatory Networks Using Spin”, 2011 IEEE BioInformatics and BioMedicine, Atlanta, Georgia, ISBN 978-0-7695-4574-5, 304-308, 2011

5.      Zurah, Jamil Ahmad and Umar Niazi ,"Dynamic Modeling of the Regulatory Network of NF-kB Activation in HIV-1 ”, International Conference on Computer Networks and Information Technology 2011 (ICCNIT).  pages 47-51. 2011

6.      Jamil Ahmad , Javeria Ashraf and Umar Niazi,“Qualitative Modeling & Analysis of Regulatory Network of Indoleamine 2, 3-dioxygenase on Tumour Immunce Escape”, International Conference on Computer Networks and Information Technology 2011 (ICCNIT).  pages 41-45. 2011

7.       Jamil Ahmad , Uzma and Umar Niazi. “ Discrete Modelling of P53 feedback loop”, IEEE GrC 2011, ISBN 978-1-4577-0370-6, p. 37-41, 2011

8.       Jamil Ahmad and Olivier Roux, Invariance Kernel of Biological Regulatory Networks,

            IJDBM, 2010, Vol. 4, No. 5 pp. 553-570

9.       Jamil Ahmad, Jeremie Bourdon, Damien Eveillard, Jonathan Fromentin, Olivier Roux, and Christine Sinoque. Temporal constraints of a gene regulatory network: refining a qualitative Simulation. BioSystem, 2009, 98 (2009) 149-159, Dec 2009

10.    J. Ahmad, O. Roux, G. Bernot, J.-P. Comet and A. Richard. Analysing formal models of genetic regulatory networks with delays: Applications to lambda phage and T-cell activation systems. Int. J. Bioinformatics Research and Applications, 4(3):240-262, 2008

11.   J. Ahmad, G. Bernot, J.-P. Comet, D. Lime and O. Roux. Hybrid modelling and dynamical analysis of gene regulatory networks with delays. ComPlexUs, 3(4):231-251, 2007

12.  10. Jamil Ahmad and Olivier Roux, Invariance Kernel of Biological Regulatory Networks, BIBM '08: Proceedings of the 2008 IEEE International Conference on Bioinformatics and Biomedicine,135-140, IEEE Computer Society

13.  Jamil Ahmad, Adrien Richard, Gilles Bernot, Jean-Paul Comet, and Olivier Roux. Delays in Biological Regulatory Networks (BRN). In International Workshop on Bioinformatics Research and Applications, (IWBRA'06), volume 3992 of Lecture Notes in Computer Science, pages 887-894 , Reading, UK, May 2006

14.   Jamil Ahmad, Temporal Modeling and Verification of Biological Regulatory Networks (BRN), MOVEP 2006, France

Posters

J. Ahmad, A. Richard, G. Bernot, J.-P. Comet, O. Roux. Delays in Biological Regulatory networks, IPG'05, Lyon, France, December 1-2, 2005


 

         PhD Thesis


          Jamil Ahmad, Hybrid Modeling and Dynamical Analysis of Biological Regulatory
         Networks with Delays, Ecole Centrale de Nantes, France, 2009


Scientific Forums


 


• International Conference on Computer Networks and Information Technology, July 11 - 13 2011,

   Bara Gali Campus, KPK, Pakistan

• Symposium on Emerging Massively Parallel Computer Architecture and Applications in scientific

  Simulations, 06 April 2011, RCMS NUST Islamabad

• Seminar on “Bioinformatics and the Pakistani Industries”, November 2010, IIU Islamabad

• International Symposium on Frontiers fo Computational Sciences 7-8 June 2010, Islamabad Pakistan

• Toward Systems Biology, 8-10 October 2007,Université Joseph Fourier - Grenoble - France
• Summer school ETR2007: Real Time Systems,3-7 September 2007, IRCCyN-ECN Nantes France.
• Advanced Introduction to Genomical Biology, 2-6 October 2006 at the Epigenomics Project,

  Genopole®, Tower Évry2, 10th floor, 523 Terrasses de l'Agora, 91000 Évry, France (near Paris).

• International Workshop on Bioinformatics Research and Applications (IWBRA 2006, IWBRA

  2007)
• Summer school: MoVeP 2006, 19-23 June 2006, Bordeaux, France.
• Workshop : RIAMS Lyon, 30 November 2005
• IPG, Conference, 2005, Bioinformatics, Integrative Post-Genomics.



Research Project



During my PhD, I worked on the development of the software GenoTech. The manual modeling of a Biological Regulatory Network (BRN) is a tedious job that takes hours even for a small biological regulatory network and which may result in an incorrect model.  GenoTech tool implements the kinetic logic formalism of R. Thomas to facilitate the qualitative modeling of genes/biological regulatory networks (GRN/BRN).  GenoTech has been developed in JAVA language with the following features:

 
• Graphical User Interface for the fast creation of Biological Regulatory Networks as a directed

   graph and for defining logical parameters
• Transforming a BRN into its discrete model
• Searching of the discrete graph for various behaviors (stable states and cycles)
• Transforming a BRN to hybrid model in HyTech format
• Saving the discrete model in dot format

 


Job Experience



Assistant Professor of Computer Science (7th Feb 2010 to date)

Lecturer in Computer Science (1999 to 2004), NUST at College of Aeronautical Engineering Risalpur campus
Lecture in Computer Science(1998-1999), Alkhair University Abbotabad
Lecturein Computer Science (1997-1998), SPS college SWAT

 

Professional Activities


Member, Program Committee, International Conference on Computer Networks and

  Information Technology, July 11 - 13 2011

• Member, Board of Studies of Computer Science, University of Peshawar

• Member, Pakistan France Alumni Network (PFAN), Embassy of France in Islamabad.



Teaching



Model Checking, Computational Biology, Artificial Intelligence, Software Engineering, Computer languages (Java, C, C++, Assembly), Digital logic, Compiler Construction and Computer Graphics



Verification tools



HyTech: The HYbrid TECHnology Tool
PHAVer : Polyhedral Hybrid Automaton Verifyer
UPPAAL: Modeling and Analysis of Real Time Systems
SPIN: Formal verification of distributed software system
PRISM: Probabilistic model checker, a tool for formal modelling and analysis of systems which exhibit random or probabilistic behavior

SpaceEx: Reachability and safety verification of continuous and hybrid systems


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